Biofunctionalization on Alkylated Silicon Substrate Surfaces via “Click” Chemistry

Organometallic chemistry on silicon and germanium surfaces.

DNA microarrays on silicon surfaces through thiol-ene chemistry.

The potential of thiol-ene chemistry as a selective strategy to functionalize silicon materials for DNA microarraying is demonstrated and applied to discriminate genetic variations.

Biodegradable microcapsules designed via 'click' chemistry.

Dextrans modified with alkyne and azide groups through hydrolysable carbonate esters form degradable microcapsules after Cu(I) catalysed 'click' reaction between azides and alkynes yielding triazole cross-links.

Phosphatidylcholine-derived bolaamphiphiles via click chemistry.

The copper-catalyzed azide alkyne cycloaddition is employed to modify phosphatidylcholine precursors with sn-2 acyl chains containing terminal alkyne or azide groups. Although the reactions are conducted as biphasic dispersions, the yields are essentially quantitative. Bolaamphiphiles are formed by simply clicking together two phosphatidylcholine alkyne precursors to a central bisazide scaffold...

Peptide conjugation via CuAAC 'click' chemistry.

The copper (I)-catalyzed alkyne azide 1,3-dipolar cycloaddition (CuAAC) or 'click' reaction, is a highly versatile reaction that can be performed under a variety of reaction conditions including various solvents, a wide pH and temperature range, and using different copper sources, with or without additional ligands or reducing agents. This reaction is highly selective and can be performed in th...